rs77010315

A SNP in the SLC36A2 gene on chromosome 5. Its most notable genotype is A;A: Hyperglycinuria (or more rarely, iminoglycinuria)

Gene
SLC36A2
Location
Chr 5151,343,594 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadHyperglycinuria (or more rarely, iminoglycinuria)Very important · 4.0
  2. A;CBadHyperglycinuria (tendency to have kidney stones)Important · 3.1
  3. C;CGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

SLC36A2 gene, c.260G>T, p.Gly87Val, G87V Heterozygous genotypes predispose to hyperglycinuria; homozygous mutant genotypes lead to iminoglycinuria but only when haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19 is also present.

A;A

See discussion and links at rs77010315

A;C

see links to OMIM and ClinVar at rs77010315

Source and license

Adapted from rs77010315 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.