rs77010898
A SNP in the CFTR gene on chromosome 7. Its most notable genotype is A;G: Cystic fibrosis allele (carrier)
- Gene
- CFTR
- Location
- Chr 7117,642,566 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CFTR SNPs
- i4000292D;Dcystic fibrosisVery important
- rs74551128A;ACystic fibrosisVery important
- rs113993960-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- rs199826652-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- i4000309A;ACystic FibrosisVery important
- i4000294A;ACystic FibrosisVery important
- i4000296T;TCystic FibrosisVery important
- i4000297A;ACystic FibrosisVery important
Notes
From SNPedia
Notes
rs77010898, also known as Trp1282X, W1282X, W1282* and 3846G>A, is a SNP in the CFTR gene considered pathogenic for cystic fibrosis. The W1282X mutation is reported to be the most common cystic fibrosis mutation in Ashkenazi Jews, representing 50% of more all CFTR mutations reported (in that population). An article about a nonprofit, Emily's Entourage, focusing on developing treatments for patients with CFTR nonsense mutations such as W1282X, is available here. In 23andMe, rs77010898 may be referred to by at least 3 other names: i4000309, i5012037, and i6056299. FTDNA & MyHeritage name: VG07S29451
A;G
Unaffected if other CF allele is normal; see discussion.
Source and license
Adapted from rs77010898 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.