rs772701127

A SNP in the MFN2 gene on chromosome 1. Its most notable genotype is T;T: Charcot-Marie-Tooth disease, type 2A (predicted)

Gene
MFN2
Location
Chr 112,007,074 (GRCh38)
Highest magnitude
5.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TBadCarrier of a Charcot-Marie-Tooth disease mutationImportant · 3.0
  3. T;TMost notableBadCharcot-Marie-Tooth disease, type 2A (predicted)Very important · 5.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MFN2 SNPs

All MFN2 SNPs

Notes

From SNPedia

Notes

rs772701127, also known as c.1894C>T, p.Arg632Trp and R632W, represents a variant in the MFN2 gene on chromosome 1. When inherited recessively, the rs772701127(T) variant is reported to lead to a relatively mild and late-onset form of Charcot-Marie-Tooth disease, type 2A.

C;T

Unaffected in absence of a second MFN2 gene mutation.

T;T

see discussion at rs772701127

Source and license

Adapted from rs772701127 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.