rs776746(C;C)

CYP3A5*3 homozygote; CYP3A5 non-expressor

Magnitude
2.5Worth knowing
Repute
Bad
Frequency
45%Average of 11 populations
On SNPedia
rs776746(G;G)Minus strand
Gene
CYP3A5

Frequency

Share of people with C;C in each HapMap population.

  • European ancestry (Utah)93%
  • Tuscan89%
  • Gujarati Indian56%
  • Mexican ancestry (Los Angeles)56%
  • Chinese (Denver)56%
  • Japanese (Tokyo)53%
  • Han Chinese (Beijing)52%
  • Maasai (Kenya)23%
  • African ancestry (Southwest US)9%
  • Luhya (Kenya)3%
  • Yoruba (Nigeria)<1%

Other genotypes of rs776746

  1. T;TGoodreference alleleTypical · 0.021% of people
  2. C;TNot ratedcarrier of 1 nonfunctional CYP3A5 allele; drug metabolism affectsWorth knowing · 2.034% of people

All about rs776746

Notes

From SNPedia

Impacts metabolism of tacrolimus, an immunosuppressive drug used in organ transplantation. This is the most common phenotype in caucasian and many other populations. Only in africans is expressing the gene common.

Source and license

Adapted from rs776746(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.