rs7794745
A SNP in the CNTNAP2 gene on chromosome 7. Its most notable genotype is A;T: slightly increased risk for autism
- Gene
- CNTNAP2
- Location
- Chr 7146,792,514 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 48%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodnormal risk (for autism)
- A;TMost notableBadslightly increased risk for autism
- T;TBadslightly increased risk for autism
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 27% A;T 42% T;T 31%
- European ancestry (Utah)A;A 48% A;T 42% T;T 11%
- Han Chinese (Beijing)A;A 37% A;T 42% T;T 20%
- Japanese (Tokyo)A;A 42% A;T 43% T;T 15%
- Yoruba (Nigeria)A;A 1% A;T 21% T;T 78%
- African ancestry (Southwest US)A;A 7% A;T 49% T;T 44%
- Chinese (Denver)A;A 39% A;T 50% T;T 12%
- Gujarati IndianA;A 35% A;T 57% T;T 8%
- Luhya (Kenya)A;A <1% A;T 32% T;T 67%
- Mexican ancestry (Los Angeles)A;A 48% A;T 43% T;T 9%
- Maasai (Kenya)A;A 1% A;T 34% T;T 65%
- TuscanA;A 38% A;T 51% T;T 11%
Related
Conditions, medicines and genes
Other CNTNAP2 SNPs
- rs2710102A;ADelayed childhood speech.Worth knowing
- rs17236239G;Ghigher risk for speech development delay and/or impairmentWorth knowing
- rs851715T;Trisk of nonsense-word repetition problems if speech-impairedMinor
- rs759178C;Chigher risk of speech development delay and/or impairmentTypical
- rs802568T;Tcommon in complete genomicsTypical
- rs1358075T;Tcommon genotypeTypical
- rs1718101C;CNo summary available.Typical
- rs2538976T;TNo summary available.Typical
Notes
From SNPedia
Show notes, about 120 words
A common SNP in the CNTNAP2 gene, rs7794745, is associated with increased risk for autism based on a study of 148 affected children from families with two more autistic children. Related article A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders? A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.
Source and license
Adapted from rs7794745 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.