rs80357563

A SNP. Its most notable genotype is -;A: BRCA1 variant considered pathogenic for breast cancer

Gene
None listed
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;-Goodcommon/normalTypical · 0.0
  2. -;AMost notableBadBRCA1 variant considered pathogenic for breast cancerVery important · 6.0

On SNPedia: (-;-), (-;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs80357563, also known as 1129insA, c.1010_1011insA and p.Glu337?fs, is a variant in the BRCA1 gene considered pathogenic for breast cancer in ClinVar.

-;A

See details at rs80357563

Source and license

Adapted from rs80357563 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.