rs80358045

A SNP. Its most notable genotype is C;T: BRCA1 variant considered pathogenic for breast cancer

Gene
None listed
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableBadBRCA1 variant considered pathogenic for breast cancerVery important · 6.0
  2. C;CGoodcommon/normalTypical · 0.0
  3. A;CBadBRCA1 variant considered pathogenic for breast cancerVery important · 6.0

SNPedia records rs80358045 on the minus strand: (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.80+5G>T and also c.80+5G>A; both are likely to be pathogenic for breast cancer according to ClinVar

C;T

see details via ClinVar sidebar/box on associated SNP/rs# page.

A;C

see details via ClinVar sidebar/box on associated SNP/rs# page.

Source and license

Adapted from rs80358045 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.