rs8176058

A SNP in the KEL gene on chromosome 7. Its most notable genotype is A;A: KELL blood group; K antigen (K/K)

Gene
KEL
Location
Chr 7142,957,921 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon; Kell group, k antigen (k/k)Typical · 0.097% of people
  2. A;GNot ratedKELL Blood group; K/k heterozygoteMinor · 1.43% of people
  3. A;AMost notableNot ratedKELL blood group; K antigen (K/K)Worth knowing · 2.50% of people

SNPedia records rs8176058 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageG;G 97% A;G 3% A;A 0%
  • European ancestry (Utah)G;G 96% A;G 4% A;A 0%
  • Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
  • Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
  • Yoruba (Nigeria)G;G 99% A;G <1% A;A 0%
  • African ancestry (Southwest US)G;G 98% A;G 2% A;A 0%
  • Gujarati IndianG;G 97% A;G 3% A;A 0%
  • Mexican ancestry (Los Angeles)G;G 91% A;G 9% A;A 0%
  • Maasai (Kenya)G;G 99% A;G 1% A;A 0%
  • TuscanG;G 91% A;G 9% A;A 0%

Other KEL SNPs

All KEL SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

The K/k blood group arises from a point mutation in rs8176058, based on an amino acid change from threonine 193 (in the k antigen) to methionine 193 (in the K antigen) in the Kell glycoprotein. The K antigen is more potent at triggering an immune reaction than the k antigen.ncbi.nlm.nih.gov At the cDNA level, the change is represented by c.578C>T, or in some older literature, c.698C>T. The c.578C allele leads to the threonine (k antigen), and the c.578T allele to the methionine (K antigen). DNA-based methods in the immunohematology reference laboratory. Molecular basis of the Kell (K1) phenotype. Non-ABO Blood Groups

Source and license

Adapted from rs8176058 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.