rs828907

A SNP in the XRCC5 gene on chromosome 2. Its most notable genotype is G;T: Slightly increased risk of bladder cancer and 2x risk of developing bladder cancer in smokers

Gene
XRCC5
Location
Chr 2216,108,009 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodNormal risk of developing bladder cancerMinor · 1.054% of people
  2. G;TMost notableBadSlightly increased risk of bladder cancer and 2x risk of developing bladder cancer in smokersWorth knowing · 2.035% of people
  3. T;TBadIncreased risk of bladder cancer and 2x risk of developing bladder cancer in smokersWorth knowing · 2.011% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 54% G;T 35% T;T 11%
  • European ancestry (Utah)G;G 28% G;T 48% T;T 24%
  • Han Chinese (Beijing)G;G 64% G;T 32% T;T 4%
  • Japanese (Tokyo)G;G 62% G;T 30% T;T 8%
  • Yoruba (Nigeria)G;G 67% G;T 31% T;T 2%
  • African ancestry (Southwest US)G;G 65% G;T 32% T;T 4%
  • Chinese (Denver)G;G 67% G;T 29% T;T 4%
  • Gujarati IndianG;G 19% G;T 47% T;T 35%
  • Luhya (Kenya)G;G 75% G;T 22% T;T 3%
  • Mexican ancestry (Los Angeles)G;G 59% G;T 22% T;T 19%
  • Maasai (Kenya)G;G 55% G;T 41% T;T 4%
  • TuscanG;G 37% G;T 48% T;T 15%

Conditions, medicines and genes

Other XRCC5 SNPs

All XRCC5 SNPs

Notes

From SNPedia

Notes

rs828907, also known as G-1401T, is a SNP in the Ku80 gene. A study of 288 Chinese patients with bladder cancer and 288 age- and gender-matched healthy controls found that the rs828907(T) allele conferred a significant (p=0.0055) increased risk of bladder cancer. In association with smoking, the (G;T) and (T;T) genotypes conferred a 2x risk (CI:1.232-3.419) for bladder cancer. correlated with oral cancer susceptibility

Source and license

Adapted from rs828907 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.