rs9288516

A SNP in the XRCC5 gene on chromosome 2. Its most notable genotype is A;A: 2x higher risk for hepatocellular cancer

Gene
XRCC5
Location
Chr 2216,188,541 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
AncestryDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated2x higher risk for hepatocellular cancerWorth knowing · 2.013% of people
  2. A;TNot rated2x higher risk for hepatocellular cancerWorth knowing · 2.025% of people
  3. T;TGoodcommon in complete genomicsTypical · 0.062% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 13% A;T 25% T;T 62%
  • European ancestry (Utah)A;A 0% A;T 0% T;T 100%
  • Han Chinese (Beijing)A;A 22% A;T 53% T;T 24%
  • Japanese (Tokyo)A;A 30% A;T 48% T;T 23%
  • Yoruba (Nigeria)A;A 0% A;T 0% T;T 100%

Other XRCC5 SNPs

All XRCC5 SNPs

Notes

From SNPedia

Notes

rs9288516 is a SNP in the XRCC5 gene. A study of ~700 Chinese patients with hepatocellular carcinoma (HCC) compared to controls indicated an increased risk for rs9288516(A) carriers (odds ratio 2.02, CI: 1.42-2.86, TA+AA versus TT) even after Bonferroni correction (P(corrected) = 0.002). The effect was more significant in HBsAg infected subjects than non-infected subjects.

Source and license

Adapted from rs9288516 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.