rs841
A SNP in the GCH1 gene on chromosome 14. Its most notable genotype is A;A: decreased baroreflex sensitivity, heart rate variability, and in women, hypertension
- Gene
- GCH1
- Location
- Chr 1454,843,774 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 27%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;AMost notableBaddecreased baroreflex sensitivity, heart rate variability, and in women, hypertension
SNPedia records rs841 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 52% A;A 8%
- European ancestry (Utah)G;G 51% A;A 5%
- Han Chinese (Beijing)G;G 42% A;A 14%
- Japanese (Tokyo)G;G 37% A;A 18%
- Yoruba (Nigeria)G;G 56% A;A 5%
- African ancestry (Southwest US)G;G 55% A;A 4%
- Chinese (Denver)G;G 44% A;A 12%
- Gujarati IndianG;G 71% A;A 2%
- Luhya (Kenya)G;G 57% A;A 5%
- Mexican ancestry (Los Angeles)G;G 40% A;A 7%
- Maasai (Kenya)G;G 49% A;A 13%
- TuscanG;G 75% A;A 2%
Related
Other GCH1 SNPs
- rs886039379-;ATDystonia, dopa-responsiveVery important
- rs41298442C;CDystonia (dopa-responsive) from homozygous GCH1 mutationVery important
- rs104894433A;Gdystonia due on GCH1 loss-of-function mutationVery important
- rs104894436A;CGCH1-deficient dopa-responsive dystonia (likely)Very important
- rs104894437A;Tdystonia due on GCH1 loss-of-function mutationVery important
- rs104894438C;Tdystonia due on GCH1 loss-of-function mutationVery important
- rs104894439C;Gdystonia due on GCH1 loss-of-function mutationVery important
- rs104894440G;Tdystonia due on GCH1 loss-of-function mutationVery important
Notes
From SNPedia
Notes
rs841, also known as C+243T or C59038T, is a SNP in the 3' UTR of the GTP cyclohydrolase 1 GCH1 gene on chromosome 14. For the associations reported for rs841(T;T), see .
A;A
In addition to the effects listed in the summary, tight linkage disequilibrium has been observed between this SNP and the "X" GCH1 gene haplotype known as gs224 here in SNPedia.
Source and license
Adapted from rs841 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.