rs863223750
A SNP in the SMAD3 gene on chromosome 15. Its most notable genotype is G;T: Familial thoracic aortic aneurysms and dissections (FTAAD)
- Gene
- SMAD3
- Location
- Chr 1567,066,236 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- G;TMost notableBadFamilial thoracic aortic aneurysms and dissections (FTAAD)
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SMAD3 SNPs
- rs387906851C;TLoeys-Dietz SyndromeVery important
- rs387906852A;GLoeys-Dietz SyndromeVery important
- rs387906856G;TLoeys-Dietz SyndromeVery important
- rs587776880-;ATLoeys-Dietz SyndromeVery important
- rs587776881-;ALoeys-Dietz SyndromeVery important
- rs587776882-;GLoeys-Dietz SyndromeVery important
- rs730880215A;GLoeys-Dietz SyndromeVery important
- rs753486471A;CFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
Source and license
Adapted from rs863223750 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.