rs869312880

A SNP in the REEP1 gene on chromosome 2. Its most notable genotype is C;T: Hereditary spastic paraplegia, type 31

Gene
REEP1
Location
Chr 286,232,624 (GRCh38)
Highest magnitude
7.1Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableBadHereditary spastic paraplegia, type 31Very important · 7.1
  2. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs869312880 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs869312880, also known as c.595+1G>A, represents a rare mutation in the REEP1 gene on chromosome 2. Inherited as an autosomal dominant, the minor allele is considered pathogenic for a type of hereditary spastic paraplegia, listed in OMIM as Spastic paraplegia 31.

C;T

see rs869312880

Source and license

Adapted from rs869312880 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.