rs876660109

A SNP. Its most notable genotype is A;G: Possibly increased breast cancer risk, but see discussion

Gene
None listed
Highest magnitude
2.2Worth knowing
Tested on
Not on consumer chips

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon/normalTypical · 0.0
  2. A;GMost notableBadPossibly increased breast cancer risk, but see discussionWorth knowing · 2.2

SNPedia records rs876660109 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.3089C>T (p.Thr1030Ile or T1030I) This missense variant in the PALB2 gene is reported based on a functional assay published in 2019 to significantly reduce DNA repair efficiency, and thereby to *potentially* significantly increase breast cancer risk. However, the extent of increased risk is unknown.

A;G

see discussion and links via main rs-page

Source and license

Adapted from rs876660109 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.