rs924607

A SNP in the LOC100996325 gene on chromosome 5. Its most notable genotype is T;T: in childhood acute lymphoblastic leukemia patients, worse response to vincristine

Gene
LOC100996325
Location
Chr 5609,978 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.058% of people
  2. C;TGoodcommon/normalTypical · 0.033% of people
  3. T;TMost notableBadin childhood acute lymphoblastic leukemia patients, worse response to vincristineMinor · 1.59% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 58% C;T 33% T;T 9%
  • European ancestry (Utah)C;C 39% C;T 44% T;T 17%
  • Han Chinese (Beijing)C;C 31% C;T 53% T;T 17%
  • Japanese (Tokyo)C;C 53% C;T 36% T;T 11%
  • Yoruba (Nigeria)C;C 83% C;T 16% T;T <1%
  • African ancestry (Southwest US)C;C 81% C;T 18% T;T 2%
  • Chinese (Denver)C;C 53% C;T 39% T;T 8%
  • Gujarati IndianC;C 42% C;T 47% T;T 12%
  • Luhya (Kenya)C;C 91% C;T 9% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 55% C;T 36% T;T 9%
  • Maasai (Kenya)C;C 82% C;T 17% T;T <1%
  • TuscanC;C 28% C;T 49% T;T 24%

Conditions, medicines and genes

Notes

From SNPedia

Notes

In a study of ~300 patients with childhood acute lymphoblastic leukemia (ALL) treated with vincristine, rs924607(T;T) patients, 28 of 50 (56%) developed at least 1 episode of grade 2 to 4 peripheral neuropathy. This was a significantly higher rate than in patients with (C;C) or (C;T) genotypes (58/271 patients; p&#8201;=&#8201;2.4&#215;10e-6). The severity of neuropathy was also greater in (T;T) patients.

T;T

(T;T) pediatric ALL patients being treated with vincristine have twice the risk of developing peripheral neuropathies compared to (C;C) and (C;T) patients, based on a preliminary study of ~300 patients.

Source and license

Adapted from rs924607 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.