rs926103

A SNP in the SH2D2A gene on chromosome 1. Its most notable genotype is T;T: Possible increased risk of multiple sclerosis if SH2D2A promoter GA repeat=16

Gene
SH2D2A
Location
Chr 1156,815,190 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadPossible increased risk of multiple sclerosis if SH2D2A promoter GA repeat=16Minor · 1.021% of people
  2. C;TGoodNo increased risk.Typical · 0.043% of people
  3. C;CGoodNo increased risk.Typical · 0.036% of people

SNPedia records rs926103 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 21% C;T 43% C;C 36%
  • European ancestry (Utah)T;T 48% C;T 52% C;C 0%
  • Han Chinese (Beijing)T;T <1% C;T 24% C;C 75%
  • Japanese (Tokyo)T;T 5% C;T 30% C;C 66%
  • Yoruba (Nigeria)T;T 57% C;T 40% C;C 4%
  • African ancestry (Southwest US)T;T 34% C;T 48% C;C 18%
  • Chinese (Denver)T;T 5% C;T 32% C;C 64%
  • Mexican ancestry (Los Angeles)T;T 9% C;T 53% C;C 38%
  • Maasai (Kenya)T;T 22% C;T 59% C;C 19%
  • TuscanT;T 14% C;T 50% C;C 36%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 290 words

Rs926103 is located within the SH2D2A gene on Chromosome 1. SH2D2A encodes an adapter protein thought to function in T-cell signal transduction. A study in the Journal for Neuroimmunology reported that 16 repeats repeat of GA after the (A;A) allele at this SNP is associated with multiple sclerosis in Norwegian, Danish and Swedish sample sets. The study concludes that the SH2D2A gene may contribute to susceptibility to MS. This study has yet to be verified or reproduced in any subsequent research. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis The fact that this is a mixture of a snp and a repeat makes this an interesting test case for Promethease

T;T

Possible increased risk of multiple sclerosis if SH2D2A promoter GA repeat=16. See The SH2D2A gene and susceptibility to multiple sclerosis. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis

C;T

Not reported to be associated with an increased risk of multiple sclerosis. See The SH2D2A gene and susceptibility to multiple sclerosis. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis

C;C

Not reported to be associated with an increased risk of multiple sclerosis. See The SH2D2A gene and susceptibility to multiple sclerosis. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis

References

Source and license

Adapted from rs926103 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.