rs9266406

A SNP in the DHFRP2 gene on chromosome 6. Its most notable genotype is A;A: Slightly increased (>2.3x) risk for Behcet's disease

Gene
DHFRP2
Location
Chr 631,368,641 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadSlightly increased (>2.3x) risk for Behcet's diseaseWorth knowing · 2.09% of people
  2. A;GBadSlightly increased risk for Behcet's diseaseWorth knowing · 2.042% of people
  3. G;GGoodcommon/normalTypical · 0.049% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 9% A;G 42% G;G 49%
  • European ancestry (Utah)A;A 6% A;G 30% G;G 64%
  • Han Chinese (Beijing)A;A 12% A;G 51% G;G 37%
  • Japanese (Tokyo)A;A 12% A;G 44% G;G 43%
  • Yoruba (Nigeria)A;A 8% A;G 45% G;G 48%
  • African ancestry (Southwest US)A;A 4% A;G 28% G;G 68%
  • Chinese (Denver)A;A 13% A;G 53% G;G 34%
  • Gujarati IndianA;A 13% A;G 52% G;G 36%
  • Luhya (Kenya)A;A 4% A;G 39% G;G 57%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 38% G;G 55%
  • Maasai (Kenya)A;A 12% A;G 36% G;G 52%
  • TuscanA;A 9% A;G 43% G;G 48%

Other DHFRP2 SNPs

All DHFRP2 SNPs

Notes

From SNPedia

Notes

A 2012 study of ~600 Chinese patients with Behcet's disease indicated an association with rs9266406(A); the odds ratio was 2.3 (CI: 1.7-2.9, p = 1.9e-10). This SNP was one of several found in one of three linkage blocks in the region showing association with Behcet's disease; the strongest association was for rs4959053, found in one of the other linkage blocks.

A;A

see rs9266406

A;G

see rs9266406

Source and license

Adapted from rs9266406 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.