rs7743761

A SNP in the DHFRP2 gene on chromosome 6. Its most notable genotype is A;A: 20x increased risk of Ankylosing Spondylitis.

Gene
DHFRP2
Location
Chr 631,368,323 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad20x increased risk of Ankylosing Spondylitis.Worth knowing · 2.012% of people
  2. A;CBad4.6x increased risk of Ankylosing Spondylitis.Worth knowing · 2.044% of people
  3. C;CGoodNormal (lower) risk of Ankylosing Spondylitis.Minor · 1.945% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 12% A;C 44% C;C 45%
  • European ancestry (Utah)A;A 3% A;C 28% C;C 69%
  • Han Chinese (Beijing)A;A 8% A;C 51% C;C 41%
  • Japanese (Tokyo)A;A 18% A;C 45% C;C 37%
  • Yoruba (Nigeria)A;A 15% A;C 41% C;C 43%
  • African ancestry (Southwest US)A;A 14% A;C 58% C;C 28%
  • Chinese (Denver)A;A 10% A;C 37% C;C 52%
  • Gujarati IndianA;A 11% A;C 46% C;C 44%
  • Luhya (Kenya)A;A 16% A;C 46% C;C 38%
  • Mexican ancestry (Los Angeles)A;A 19% A;C 48% C;C 33%
  • Maasai (Kenya)A;A 8% A;C 38% C;C 54%
  • TuscanA;A 9% A;C 40% C;C 51%

Conditions, medicines and genes

Other DHFRP2 SNPs

All DHFRP2 SNPs

Notes

From SNPedia

Show notes, about 170 words

Each A allele at rs7743761 is associated with 4.6x higher risk of ankylosing spondylitis, according to a 2007 publication.

A;A

Greatly increased odds (but still only about 2%) of this disease. Ankylosing Spondylitis is a rare autoimmune disease that causes inflammation of the spine and joints. The usual age of onset is from the late teens to 40 years of age. Some people with ankylosing spondylitis have onset of symptoms when younger than 16 years. This form of AS is referred to as juvenile-onset ankylosing spondylitis. Reference: http://www.emedicinehealth.com/ankylosing_spondylitis_rheumatologic_perspective/article_em.htm

A;C

Substantially increased (but still only 0.5%) risk of this rare autoimmune disease that causes inflammation of the spine and joints. Based on preliminary research. Age of onset is usually between 15 and 25, so if you are older than that, there's not much need for worry.

C;C

Normal, very low risk (1 in a thousand) of the rare autoimmune disease that causes inflammation of the spine and joints. Based on preliminary research.

Source and license

Adapted from rs7743761 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.