rs9282860
A SNP in the STK11 gene on chromosome 19. Its most notable genotype is T;T: slightly increased risk for multiple sclerosis in females
- Gene
- STK11
- Location
- Chr 191,221,162 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TBadslightly increased risk for multiple sclerosis in females
- T;TMost notableBadslightly increased risk for multiple sclerosis in females
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other STK11 SNPs
- rs9282859C;GSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913315A;GSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913321-;CSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913322C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913324C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853075A;CLikely miscall in Ancestry v2c data; otherwise, STK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853076A;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853077C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
Notes
From SNPedia
Show notes, about 130 words
rs9282860 is a SNP within intron 5 of the STK11 gene; the minor allele is carried by about 7% of the population in one study. Based on sequencing of a family in which five siblings were diagnosed with multiple sclerosis (MS), rs9282860 was then screened in 654 relapsing-remitting MS patients, 100 primary progressive MS patients, and 661 controls. rs9282860(T) was found more frequently in all female patients versus controls (odds ratio 1.66, CI: 1.05-2.64, p = .032). However, it was not associated with disease duration or onset. It was significantly associated with reduced severity, with the lowest MS severity scores in patients who also harbored the HLA-DRB1*1501 allele (tagged by rs3135388 and by itself strongly associated with MS).
C;T
see discussion at rs9282860
T;T
see discussion at rs9282860
Source and license
Adapted from rs9282860 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.