rs9472817(C;C)

CC genotype increases risk of Alzheimer's in epsilon 4s.

Magnitude
2.1Worth knowing
Repute
Bad
Frequency
33%Average of 4 populations
On SNPedia
rs9472817(C;C)
Gene
SLC25A27

Frequency

Share of people with C;C in each HapMap population.

  • Yoruba (Nigeria)55%
  • Japanese (Tokyo)36%
  • European ancestry (Utah)31%
  • Han Chinese (Beijing)11%

Other genotypes of rs9472817

  1. C;GBadCG genotype increases Alzheimer's risk relative to GG in epsilon 4sWorth knowing · 2.144% of people
  2. G;GGoodReduces risk of Alzheimer's in those with epsilon 4Worth knowing · 2.123% of people

All about rs9472817

Notes

From SNPedia

The article on the SNP page noted that those with CC and APOE epsilon 4 had increased risk of Alzheimer's as compared with those only with epsilon 4. This result will need to be confirmed in a larger study. Also it is not clear what the implications are for those with homozygous epsilon 4 genotype.

Source and license

Adapted from rs9472817(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.