rs9472817(C;G)

CG genotype increases Alzheimer's risk relative to GG in epsilon 4s

Magnitude
2.1Worth knowing
Repute
Bad
Frequency
44%Average of 4 populations
On SNPedia
rs9472817(C;G)
Gene
SLC25A27

Frequency

Share of people with C;G in each HapMap population.

  • Han Chinese (Beijing)60%
  • European ancestry (Utah)48%
  • Japanese (Tokyo)38%
  • Yoruba (Nigeria)29%

Other genotypes of rs9472817

  1. C;CMost notableBadCC genotype increases risk of Alzheimer's in epsilon 4s.Worth knowing · 2.133% of people
  2. G;GGoodReduces risk of Alzheimer's in those with epsilon 4Worth knowing · 2.123% of people

All about rs9472817

Notes

From SNPedia

The risk of AD among those carrying an epsilon 4 and heterozygote gentotype at rs9472817 was intermediate between the other two homozygous genotypes. In the study cited for this SNP no specific p value is given for this heterozygote zygote result, though the CG genotype when considered in conjunction with epsilon 4 carriage yielded a p-value of p=1.02 * 10-13.

Source and license

Adapted from rs9472817(C;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.