rs966423

A SNP in the DIRC3 gene on chromosome 2. Its most notable genotype is C;C: Possible elevated thyroid cancer risk

Gene
DIRC3
Location
Chr 2217,445,617 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadPossible elevated thyroid cancer riskWorth knowing · 2.054% of people
  2. C;TBadPossible elevated thyroid cancer riskWorth knowing · 2.036% of people

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 54% C;T 36%
  • European ancestry (Utah)C;C 18% C;T 56%
  • Han Chinese (Beijing)C;C 58% C;T 39%
  • Japanese (Tokyo)C;C 47% C;T 45%
  • Yoruba (Nigeria)C;C 69% C;T 29%
  • African ancestry (Southwest US)C;C 58% C;T 33%
  • Chinese (Denver)C;C 64% C;T 29%
  • Gujarati IndianC;C 56% C;T 36%
  • Luhya (Kenya)C;C 79% C;T 18%
  • Mexican ancestry (Los Angeles)C;C 53% C;T 40%
  • Maasai (Kenya)C;C 72% C;T 25%
  • TuscanC;C 20% C;T 43%

Other DIRC3 SNPs

All DIRC3 SNPs

Notes

From SNPedia

Show notes, about 120 words

C;C

After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer.

C;T

After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer.

Source and license

Adapted from rs966423 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.