rs9934438

A SNP in the VKORC1 gene on chromosome 16. Its most notable genotype is A;A: coumadin resistance

Gene
VKORC1
Location
Chr 1631,093,557 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadcoumadin resistanceWorth knowing · 2.530% of people
  2. G;GGoodcommon in clinvarTypical · 0.045% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 30% G;G 45%
  • European ancestry (Utah)A;A 20% G;G 40%
  • Han Chinese (Beijing)A;A 91% G;G 0%
  • Japanese (Tokyo)A;A 81% G;G 0%
  • Yoruba (Nigeria)A;A 0% G;G 94%
  • African ancestry (Southwest US)A;A 5% G;G 84%
  • Chinese (Denver)A;A 83% G;G <1%
  • Gujarati IndianA;A 2% G;G 65%
  • Luhya (Kenya)A;A 0% G;G 88%
  • Mexican ancestry (Los Angeles)A;A 22% G;G 29%
  • Maasai (Kenya)A;A 2% G;G 70%
  • TuscanA;A 22% G;G 28%

Other VKORC1 SNPs

All VKORC1 SNPs

Notes

From SNPedia

Notes

risk of aortic calcification was calculated, adjusted for potential confounders. The T allele frequency of the VKORC1 1173C>T polymorphism was 38.8%. 1185 (37.2%) persons were homozygous CC, 1529 (48,0%) were heterozygous CT and 473 (14.8%) were homozygous TT. Persons with at least one T-allele had a statistically significant 19% (95% CI 2 to 40%) risk increase of calcification of the aortic far wall compared to CC homozygous persons

Source and license

Adapted from rs9934438 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.