i3003626

A SNP in the CCR5 gene on chromosome 3. Its most notable genotype is D;D: resistant to HIV

Gene
CCR5
Location
Chr 346,414,947 (GRCh38)
Highest magnitude
5.0Very important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. D;DMost notableGoodresistant to HIVVery important · 5.0
  2. D;IGoodNo summary available.Worth knowing · 2.0
  3. I;IBadNo summary available.Typical · 0.0

On SNPedia: (D;D), (D;I), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CCR5 SNPs

All CCR5 SNPs

Notes

From SNPedia

Show notes, about 130 words

The public name for this SNP is rs333, and it is most commonly known as the CCR5 Delta32 (or 'Delta 32') mutation. It is discussed in numerous articles and blogs, including here and here. *II +/+: Not resistant to HIV infection; shows average time of progression to AIDS after infection. *DI Delta32/+: Not resistant to HIV infection but may have slower progression to AIDS after infection. *DD Delta32/Delta32: Resistant to infection by the most common strain of HIV people usually encounter, though protection is not complete. Resistance to HIV/AIDS

D;D

resistant to HIV. You have the donor genotype described at http://snpedia.blogspot.com/2012/12/all-i-want-for-christmas-is-cure-for-hiv.html . Also known as CCR5-Δ32.

D;I

Not HIV resistant, but possibly slower progression to AIDS if infected.

I;I

not resistant to HIV

Source and license

Adapted from i3003626 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.