rs2856758
A SNP in the CCR5 gene on chromosome 3. Its most notable genotype is A;A: common in complete genomics
- Gene
- CCR5
- Location
- Chr 346,370,170 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 8%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
Rs2856758 is a SNP in the CCR5 gene (CC-chemokine receptor type 5). Variants in CCR5 are associated with resistance to HIV infection. plosone.org Another mutation in this gene, rs333 (also known as the CCR5-delta32 deletion), is associated with resistance to HIV. This mutation may have spread in the European population in response to selection pressure from plague (Black Death) or smallpox. pnas.org Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations. Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
Source and license
Adapted from rs2856758 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.