rs333

The chemokine receptor gene CCR5 plays an important role in many immune-related processes. Delta 32 rs333, designating the CCR5-delta32 deletion of 32 nucleotides from within the gene, is perhaps the most famous allele of CCR5. 23andMe tests for this under their private identifier/name, I3003626. Individuals carrying one copy of the delta 32 allele are somewhat resistant to infection by HIV, the virus that causes AIDS, and individuals with 2 copies (delta 32 homozygotes, ~1% of Caucasians) are almost completely immune to infection by HIV. The delta 32 allele may have been selected for in European populations because it confers resistance to plague (Black Death) or smallpox. pnas.org shows the the geographic spread of the allele. thumb|300px|The geographic spread of the allele NEJM suggests decreased risk of type 1 diabetes (odds ratio, 0.54; 95% CI, 0.40 to 0.72; P=1.88x10–6 with 2 df). Does the CCR5-delta32 mutation have an entirely positive/protective role? Probably not. In patients with abdominal aortic aneurysm (AAA), the major risk is a sudden rupture - which is quite often fatal. Individuals with the delta 32 variant are more likely to have aneurysms than non-carriers, and among patients with aneurysms, delta 32 carriers are more likely to rupture than to be diagnosed in time for surgical repair. Tests for CCR-delta32 are offered by FamilyTreeDNA (FAQ), 23andMe, and possibly other direct-to-consumer genetics testing companies.

-;-

resistant to HIV. You have the donor genotype described at http://snpedia.blogspot.com/2012/12/all-i-want-for-christmas-is-cure-for-hiv.html . Also known as CCR5-Δ32. Consider becoming a marrow donor at http://marrow.org/Join/Join_the_Registry.aspx