rs1041740

A SNP in the SOD1 gene on chromosome 21. Its most notable genotype is T;T: Slight increase in cardiovascular risk?

Gene
SOD1
Location
Chr 2131,667,849 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.058% of people
  2. T;TMost notableBadSlight increase in cardiovascular risk?Minor · 1.88% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 58% T;T 8%
  • European ancestry (Utah)C;C 56% T;T 3%
  • Han Chinese (Beijing)C;C 37% T;T 18%
  • Japanese (Tokyo)C;C 34% T;T 12%
  • Yoruba (Nigeria)C;C 93% T;T 0%
  • African ancestry (Southwest US)C;C 79% T;T 0%
  • Chinese (Denver)C;C 43% T;T 12%
  • Gujarati IndianC;C 43% T;T 14%
  • Luhya (Kenya)C;C 94% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 44% T;T 11%
  • Maasai (Kenya)C;C 72% T;T 2%
  • TuscanC;C 42% T;T 14%

Other SOD1 SNPs

All SOD1 SNPs

Notes

From SNPedia

Notes

A study of ~2800 Japanese adults concluded that rs1041740(T;T) was associated with cardiovascular mortality (adjusted HR, 2.07, CI: 1.10–3.91, p = 0.0244).

T;T

see discussion at rs1041740

Source and license

Adapted from rs1041740 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.