rs121912441

A SNP in the SOD1 gene on chromosome 21. Its most notable genotype is C;T: Amyotrophic Lateral Sclerosis I114T mutation

Gene
SOD1
Location
Chr 2131,667,359 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadAmyotrophic Lateral Sclerosis I114T mutationVery important · 5.0
  2. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SOD1 SNPs

All SOD1 SNPs

Notes

From SNPedia

Notes

rs121912441, also known as c.341T>C, p.Ile114Thr and I114T, represents a rare mutation in the SOD1 gene on chromosome 21. The minor rs121912441(C) allele is considered an autosomal dominant mutation leading to amyotrophic lateral sclerosis according to two sources in ClinVar.

C;T

see rs121912441

Source and license

Adapted from rs121912441 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.