rs80265967

A SNP in the SOD1 gene on chromosome 21. Its most notable genotype is A;C: Associated with forms of Amyotrophic Lateral Sclerosis

Gene
SOD1
Location
Chr 2131,667,290 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in clinvarTypical · 0.0
  2. A;CMost notableBadAssociated with forms of Amyotrophic Lateral SclerosisVery important · 7.0
  3. C;CBadAssociated with forms of Amyotrophic Lateral SclerosisVery important · 7.0

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SOD1 SNPs

All SOD1 SNPs

Notes

From SNPedia

Notes

rs80265967, also known as D90A or less commonly Asp90Ala, is a mutation in the superoxide dismutase 1 SOD1 gene. rs80265967(C) has been associated with familial (inherited) forms of amyotrophic lateral sclerosis, in both heterozygous dominant and homozygous recessive forms.

Source and license

Adapted from rs80265967 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.