rs1042778
A SNP in the OXTR gene on chromosome 3. Its most notable genotype is T;T: Slightly lower oxytocin & empathy? Possibly higher 'callous-unemotional' trait frequency in children.
- Gene
- OXTR
- Location
- Chr 38,752,859 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 37%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 18%
- European ancestry (Utah)T;T 13%
- Han Chinese (Beijing)T;T 0%
- Japanese (Tokyo)T;T 0%
- Yoruba (Nigeria)T;T 46%
- African ancestry (Southwest US)T;T 21%
- Chinese (Denver)T;T 0%
- Gujarati IndianT;T 18%
- Luhya (Kenya)T;T 50%
- Mexican ancestry (Los Angeles)T;T 23%
- Maasai (Kenya)T;T 19%
- TuscanT;T 10%
Related
Notes
From SNPedia
Notes
blog rs1042778, rs2268490 and rs237887 in OXTR influence prosociality Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy. A study of ~120 children, followed by a replication in ~100 children, concluded that the rs1042778(T;T) genotype was associated with high levels of callous-unemotional (CU) traits in both samples.
T;T
see rs1042778 for discussion of callous-unemotional trait study and other oxytocin associations
Source and license
Adapted from rs1042778 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.