rs13316193

A SNP in the OXTR gene on chromosome 3. Its most notable genotype is C;C: slight evidence indicating increased OXTR expression, higher levels of empathy.

Gene
OXTR
Location
Chr 38,761,057 (GRCh38)
Highest magnitude
0.8Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodslight evidence indicating increased OXTR expression, higher levels of empathy.Typical · 0.819% of people
  2. C;TNot ratedNo summary available.Typical · 0.038% of people
  3. T;TBadslight evidence indicating decreased OXTR expression, higher risk of depression, higher risk of Autism Spectrum Disorder.Typical · 0.843% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 19% C;T 38% T;T 43%
  • European ancestry (Utah)C;C 21% C;T 57% T;T 23%
  • Han Chinese (Beijing)C;C 5% C;T 44% T;T 51%
  • Japanese (Tokyo)C;C 2% C;T 19% T;T 79%
  • Yoruba (Nigeria)C;C 47% C;T 34% T;T 19%

Other OXTR SNPs

All OXTR SNPs

Notes

From SNPedia

Show notes, about 140 words

The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD. The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A.

C;C

The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy.

T;T

The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Genetics of human social behavior. Oxytocin and social affiliation in humans. Parental oxytocin and early caregiving jointly shape children's oxytocin response and social reciprocity.

References

Source and license

Adapted from rs13316193 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.