rs1045881

A SNP in the NRXN1 gene on chromosome 2. Its most notable genotype is C;C: common in clinvar

Gene
NRXN1
Location
Chr 249,921,834 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.071% of people

SNPedia records rs1045881 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 71%
  • European ancestry (Utah)C;C 77%
  • Han Chinese (Beijing)C;C 78%
  • Japanese (Tokyo)C;C 74%
  • Yoruba (Nigeria)C;C 65%
  • African ancestry (Southwest US)C;C 84%
  • Chinese (Denver)C;C 71%
  • Gujarati IndianC;C 38%
  • Luhya (Kenya)C;C 72%
  • Mexican ancestry (Los Angeles)C;C 87%
  • Maasai (Kenya)C;C 77%
  • TuscanC;C 62%

Other NRXN1 SNPs

All NRXN1 SNPs

Notes

From SNPedia

Notes

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.

Source and license

Adapted from rs1045881 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.