rs2024513

A SNP in the NRXN1 gene on chromosome 2. Its most notable genotype is A;A: 1.7x higher risk for schizophrenia (among Han Chinese)

Gene
NRXN1
Location
Chr 250,924,881 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.7x higher risk for schizophrenia (among Han Chinese)Minor · 1.763% of people
  2. A;GBad1.3x higher risk for schizophrenia (among Han Chinese)Minor · 1.330% of people
  3. G;GNot ratedNo summary available.Typical · 0.06% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 63% A;G 30% G;G 6%
  • European ancestry (Utah)A;A 31% A;G 45% G;G 24%
  • Han Chinese (Beijing)A;A 64% A;G 33% G;G 3%
  • Japanese (Tokyo)A;A 67% A;G 29% G;G 5%
  • Yoruba (Nigeria)A;A 90% A;G 10% G;G <1%
  • African ancestry (Southwest US)A;A 68% A;G 32% G;G 0%
  • Chinese (Denver)A;A 68% A;G 28% G;G 4%
  • Gujarati IndianA;A 59% A;G 37% G;G 4%
  • Luhya (Kenya)A;A 89% A;G 11% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 50% A;G 36% G;G 14%
  • Maasai (Kenya)A;A 72% A;G 27% G;G 1%
  • TuscanA;A 39% A;G 46% G;G 15%

Conditions, medicines and genes

Other NRXN1 SNPs

All NRXN1 SNPs

Notes

From SNPedia

Notes

rs2024513 is a SNP in the neurexin-1 NRXN1 gene on chromosome 2p16.3. Based on a case-control study of 700+ Han Chinese patients with schizophrenia, rs2024513(A) was associated with higher risk, at an odds ratio of 1.3 (CI: 1.07 - 1.56, p=0.006).

Source and license

Adapted from rs2024513 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.