rs10485057

A SNP in the OPRM1 gene on chromosome 6. Its most notable genotype is G;G: increased risk for smoking, nicotine dependence

Gene
OPRM1
Location
Chr 6154,092,120 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.085% of people
  2. A;GNot ratednormal?Typical · 0.013% of people
  3. G;GMost notableNot ratedincreased risk for smoking, nicotine dependenceImportant · 3.01% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 85% A;G 13% G;G 1%
  • European ancestry (Utah)A;A 77% A;G 22% G;G 2%
  • Han Chinese (Beijing)A;A 91% A;G 9% G;G 0%
  • Japanese (Tokyo)A;A 96% A;G 5% G;G 0%
  • Yoruba (Nigeria)A;A 78% A;G 19% G;G 3%

Conditions, medicines and genes

Other OPRM1 SNPs

All OPRM1 SNPs

Notes

From SNPedia

Notes

rs10485057 is a SNP in the opioid receptor, mu 1 OPRM1 gene. A study of 688 Caucasian smokers (and non-smoking controls) indicated that the rare rs10485057(G) allele was associated with higher likelihood of smoking initiation and nicotine dependence.

Source and license

Adapted from rs10485057 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.