rs2281617

A SNP in the OPRM1 gene on chromosome 6. Its most notable genotype is C;C: Normal (better) response to amphetamine

Gene
OPRM1
Location
Chr 6154,166,286 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNormal (better) response to amphetamineWorth knowing · 2.053% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 53%
  • European ancestry (Utah)C;C 69%
  • Han Chinese (Beijing)C;C 33%
  • Japanese (Tokyo)C;C 31%
  • Yoruba (Nigeria)C;C 49%
  • African ancestry (Southwest US)C;C 67%
  • Chinese (Denver)C;C 38%
  • Gujarati IndianC;C 48%
  • Luhya (Kenya)C;C 42%
  • Mexican ancestry (Los Angeles)C;C 74%
  • Maasai (Kenya)C;C 65%
  • TuscanC;C 71%

Other OPRM1 SNPs

All OPRM1 SNPs

Notes

From SNPedia

Notes

Some evidence exists that the T;T and C;T genotypes are associated with less euphoria and energy in response to a given dose of a stimulant drug, e.g. dextroamphetamine, than occurs for the C;C genotype. See http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377371/, especially figure 3 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377371/figure/F3/

C;C

The main finding of the study is that subjects with genotype C/C at rs2281617 scored significantly higher on Euphoria and Energy than subjects with genotypes C/T and T/T after 10 mg amphetamine, and trends were also observed with measures of Stimulation and (lower) Sedation.

Source and license

Adapted from rs2281617 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.