rs563649

A SNP in the OPRM1 gene on chromosome 6. Its most notable genotype is C;C: common in complete genomics

Gene
OPRM1
Location
Chr 6154,086,832 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
10%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in complete genomicsTypical · 0.080% of people

SNPedia records rs563649 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 80%
  • European ancestry (Utah)C;C 88%
  • Han Chinese (Beijing)C;C 76%
  • Japanese (Tokyo)C;C 89%
  • Yoruba (Nigeria)C;C 75%
  • African ancestry (Southwest US)C;C 83%
  • Chinese (Denver)C;C 77%
  • Gujarati IndianC;C 81%
  • Luhya (Kenya)C;C 86%
  • Mexican ancestry (Los Angeles)C;C 59%
  • Maasai (Kenya)C;C 87%
  • TuscanC;C 77%

Other OPRM1 SNPs

All OPRM1 SNPs

Notes

From SNPedia

Notes

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Do genetic predictors of pain sensitivity associate with persistent widespread pain?

Source and license

Adapted from rs563649 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.