rs10488631(C;T)

2x increased risk of developing SLE; 1.6x increased risk of developing primary biliary cirrhosis; and 1.7x increased risk of developing Sjögren's syndrome

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
10%Average of 10 populations
On SNPedia
rs10488631(C;T)
Gene
TNPO3

Frequency

Share of people with C;T in each HapMap population.

  • Mexican ancestry (Los Angeles)31%
  • Gujarati Indian26%
  • European ancestry (Utah)21%
  • Tuscan14%
  • Maasai (Kenya)8%
  • African ancestry (Southwest US)2%
  • Luhya (Kenya)2%
  • Han Chinese (Beijing)<1%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs10488631

  1. C;CMost notableBad2x increased risk of developing SLE; 3.2x increased risk of developing primary biliary cirrhosis; and 3.4x increased risk of developing Sjögren's syndromeImportant · 3.0<1% of people
  2. T;TGoodNormal risk of developing SLE, primary biliary cirrhosis, and Sjögren's syndromeMinor · 1.089% of people

All about rs10488631

Source and license

Adapted from rs10488631(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.