rs104886457

A SNP in the C9orf3 gene on chromosome 9. Its most notable genotype is A;A: Fanconi Anemia

Gene
C9orf3
Location
Chr 995,101,742 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadcarrier of Fanconi anemia alleleImportant · 3.0
  3. A;AMost notableBadFanconi AnemiaVery important · 5.0

SNPedia records rs104886457 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other C9orf3 SNPs

All C9orf3 SNPs

Notes

From SNPedia

Notes

rs104886457, also known as R548* or R548X, is a SNP in the Fanconi anemia, complementation group C FANCC gene. 23andMe reports that this causative mutation for Fanconi anemia is found mainly in non-Jewish people with European ancestry. The term 23andMe uses for this SNP is i4000412.

Source and license

Adapted from rs104886457 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.