rs104895094
A SNP in the MEFV gene on chromosome 16. Its most notable genotype is C;C: Familial Mediterranean Fever, autosomal recessive
- Gene
- MEFV
- Location
- Chr 163,243,403 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- C;TBadCarrier of a familial mediterranean fever mutation
- C;CMost notableBadFamilial Mediterranean Fever, autosomal recessive
SNPedia records rs104895094 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MEFV SNPs
- i4000404T;TFamilial Mediterranean FeverVery important
- i4000406C;Cfamilial mediterranean feverVery important
- i4000410T;Tfamilial mediterranean feverVery important
- rs28940580C;GFamilial mediterranean fever (predicted)Very important
- rs61732874A;Afamilial mediterranean feverVery important
- rs61752717C;Cfamilial mediterranean feverVery important
- rs104895093-;-Familial Mediterranean FeverVery important
- rs104895097T;Tfamilial mediterranean feverVery important
Notes
From SNPedia
Notes
rs104895094, also known as c.2084A>G, p.Lys695Arg or K695R, is a SNP in the MEFV gene. The risk allele is given as (C) by 23andMe, however in dbSNP orientation, the risk allele is (G). The symptoms of familial Mediterranean fever are caused by the person's own inflammatory response; it is not an infectious disease. The condition is more common among Turks, Sephardic Jews, and people of Arab and Armenian ancestry. Non-founder mutations in the MEFV gene establish this gene as the cause of familial Mediterranean fever (FMF).
C;T
Familial Mediterranean Fever mutation carrier; unaffected unless a second MEFV gene mutation is present.
C;C
This nonfounder mutation is a known cause of reduced penetrance FMF.
Source and license
Adapted from rs104895094 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.