rs28940580
A SNP in the MEFV gene on chromosome 16. Its most notable genotype is C;G: Familial mediterranean fever (predicted)
- Gene
- MEFV
- Location
- Chr 163,243,447 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TBadfamilial Mediterranean fever
- G;TBadfamilial Mediterranean fever
- C;TBadCarrier of a familial mediterranean fever mutation
- G;GNot ratedcan be ignored for now
- C;GMost notableBadFamilial mediterranean fever (predicted)
- C;CGoodcommon in clinvar
SNPedia records rs28940580 on the minus strand: (A;A), (A;C), (A;G), (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MEFV SNPs
- i4000404T;TFamilial Mediterranean FeverVery important
- i4000406C;Cfamilial mediterranean feverVery important
- i4000410T;Tfamilial mediterranean feverVery important
- rs61732874A;Afamilial mediterranean feverVery important
- rs61752717C;Cfamilial mediterranean feverVery important
- rs104895093-;-Familial Mediterranean FeverVery important
- rs104895094C;CFamilial Mediterranean Fever, autosomal recessiveVery important
- rs104895097T;Tfamilial mediterranean feverVery important
Notes
From SNPedia
Show notes, about 130 words
rs28940580, also known as c.2040G>C, p.Met680Ile or M680I, is a SNP in the MEFV gene. The risk allele is given as (G) by 23andMe, however in dbSNP orientation, the risk allele is (C). The symptoms of familial Mediterranean fever are caused by the person's own inflammatory response; it is not an infectious disease. The condition is more common among Turks, Sephardic Jews, and people of Arab and Armenian ancestry.
C;T
Familial Mediterranean Fever mutation carrier; unaffected unless a second MEFV gene mutation is present.
G;G
At the moment, this is notable as the genotype most impacted during some recent adjustments to SNPedia. The changes relate to Orientation and StabilizedOrientation In time, this genotype will probably again report about familial Mediterranean fever.
Source and license
Adapted from rs28940580 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.