rs61732874
A SNP in the MEFV gene on chromosome 16. Its most notable genotype is A;A: familial mediterranean fever
- Gene
- MEFV
- Location
- Chr 163,243,257 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadfamilial mediterranean fever
- A;CBadCarrier of a familial mediterranean fever mutation
- C;CGoodcommon in clinvar
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MEFV SNPs
- i4000404T;TFamilial Mediterranean FeverVery important
- i4000406C;Cfamilial mediterranean feverVery important
- i4000410T;Tfamilial mediterranean feverVery important
- rs28940580C;GFamilial mediterranean fever (predicted)Very important
- rs61752717C;Cfamilial mediterranean feverVery important
- rs104895093-;-Familial Mediterranean FeverVery important
- rs104895094C;CFamilial Mediterranean Fever, autosomal recessiveVery important
- rs104895097T;Tfamilial mediterranean feverVery important
Notes
From SNPedia
Notes
rs61732874, also known as c.2230G>T, p.Ala744Ser or A744S, is a SNP in the MEFV gene. The equivalent SNP for 23andMe is i4000409. The symptoms of familial Mediterranean fever are caused by the person's own inflammatory response; it is not an infectious disease. The condition is more common among Turks, Sephardic Jews, and people of Arab and Armenian ancestry.
A;C
Familial Mediterranean Fever mutation carrier; unaffected unless a second MEFV gene mutation is present.
Source and license
Adapted from rs61732874 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.