rs10509681(C;C)

>1.81x risk of GI bleeding with some NSAID drugs

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
<1%Average of 9 populations
On SNPedia
rs10509681(C;C)
Gene
CYP2C8

Frequency

Share of people with C;C in each HapMap population.

  • European ancestry (Utah)3%
  • Tuscan2%
  • Gujarati Indian1%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Mexican ancestry (Los Angeles)0%
  • Maasai (Kenya)0%

Other genotypes of rs10509681

  1. C;TBadIncreased risk of GI bleeding with NSAIDsMinor · 1.59% of people
  2. T;TGoodNo increased risk of GI bleeding on NSAID drugsMinor · 1.090% of people

All about rs10509681

Notes

From SNPedia

The minor homozygous is rare but is likely to carry a higher risk.

Source and license

Adapted from rs10509681(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.