rs10509681(C;T)

Increased risk of GI bleeding with NSAIDs

Magnitude
1.5Minor
Repute
Bad
Frequency
9%Average of 9 populations
On SNPedia
rs10509681(C;T)
Gene
CYP2C8

Frequency

Share of people with C;T in each HapMap population.

  • European ancestry (Utah)22%
  • Tuscan21%
  • Mexican ancestry (Los Angeles)19%
  • African ancestry (Southwest US)9%
  • Gujarati Indian7%
  • Maasai (Kenya)5%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs10509681

  1. C;CMost notableBad>1.81x risk of GI bleeding with some NSAID drugsWorth knowing · 2.0<1% of people
  2. T;TGoodNo increased risk of GI bleeding on NSAID drugsMinor · 1.090% of people

All about rs10509681

Source and license

Adapted from rs10509681(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.