rs1052576(C;C)

Increased risk of multiple myeloma, B-cell neoplasms, and cancer in general

Magnitude
1.0Minor
Repute
Bad
Frequency
41%Average of 11 populations
On SNPedia
rs1052576(G;G)Minus strand
Gene
CASP9

Frequency

Share of people with C;C in each HapMap population.

  • Luhya (Kenya)69%
  • Maasai (Kenya)54%
  • Yoruba (Nigeria)52%
  • African ancestry (Southwest US)46%
  • Chinese (Denver)46%
  • Japanese (Tokyo)45%
  • Han Chinese (Beijing)39%
  • Tuscan29%
  • Mexican ancestry (Los Angeles)29%
  • European ancestry (Utah)28%
  • Gujarati Indian19%

Other genotypes of rs1052576

  1. T;TMost notableGood0.5x reduced risk of multiple myeloma, general reduced risk of cancerMinor · 1.714% of people
  2. C;TGood0.8x reduced risk of multiple myeloma, general reduced risk of cancerMinor · 1.544% of people

All about rs1052576

Notes

From SNPedia

A number of small studies with lowish p-values but low heterogeneity across studies suggest the A allele is protective against cancer. B-cell neoplasms may be particularly affected. Most studies showed a protective role for the A allele, which, by inference, means a higher (but not quantified) risk for the G allele.

Source and license

Adapted from rs1052576(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.