rs1052576(C;T)

0.8x reduced risk of multiple myeloma, general reduced risk of cancer

Magnitude
1.5Minor
Repute
Good
Frequency
44%Average of 11 populations
On SNPedia
rs1052576(A;G)Minus strand
Gene
CASP9

Frequency

Share of people with C;T in each HapMap population.

  • Tuscan55%
  • Gujarati Indian53%
  • African ancestry (Southwest US)48%
  • Han Chinese (Beijing)47%
  • Chinese (Denver)46%
  • Mexican ancestry (Los Angeles)45%
  • European ancestry (Utah)43%
  • Maasai (Kenya)42%
  • Japanese (Tokyo)41%
  • Yoruba (Nigeria)38%
  • Luhya (Kenya)28%

Other genotypes of rs1052576

  1. T;TMost notableGood0.5x reduced risk of multiple myeloma, general reduced risk of cancerMinor · 1.714% of people
  2. C;CBadIncreased risk of multiple myeloma, B-cell neoplasms, and cancer in generalMinor · 1.041% of people

All about rs1052576

Notes

From SNPedia

A number of studies with lowish p-values but low heterogeneity across studies show a reduced risk of multiple myeloma, greater in homozygotes, for the A allele. There is also a generalized reduction in cancer risk. B-cell neoplasms may be particularly affected.

Source and license

Adapted from rs1052576(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.