rs1052576(T;T)

0.5x reduced risk of multiple myeloma, general reduced risk of cancer

Magnitude
1.7Minor
Repute
Good
Frequency
14%Average of 11 populations
On SNPedia
rs1052576(A;A)Minus strand
Gene
CASP9

Frequency

Share of people with T;T in each HapMap population.

  • European ancestry (Utah)29%
  • Gujarati Indian29%
  • Mexican ancestry (Los Angeles)26%
  • Tuscan16%
  • Japanese (Tokyo)14%
  • Han Chinese (Beijing)14%
  • Yoruba (Nigeria)10%
  • Chinese (Denver)8%
  • African ancestry (Southwest US)5%
  • Maasai (Kenya)4%
  • Luhya (Kenya)4%

Other genotypes of rs1052576

  1. C;TGood0.8x reduced risk of multiple myeloma, general reduced risk of cancerMinor · 1.544% of people
  2. C;CBadIncreased risk of multiple myeloma, B-cell neoplasms, and cancer in generalMinor · 1.041% of people

All about rs1052576

Notes

From SNPedia

A number of small studies with fairly low p-values, but with low heterogeneity across studies, show a protective effect for the A allele which is greater in homozygotes.

Source and license

Adapted from rs1052576(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.