rs10757272
A SNP in the CDKN2B-AS1 gene on chromosome 9. Its most notable genotype is T;T: 1.54x increased risk for Coronary artery disease
- Gene
- CDKN2B-AS1
- Location
- Chr 922,088,261 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 47%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodNormal risk for Coronary artery disease
- C;TBad1.30x increased risk for Coronary artery disease
- T;TMost notableBad1.54x increased risk for Coronary artery disease
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 34% C;T 44% T;T 22%
- European ancestry (Utah)C;C 29% C;T 50% T;T 21%
- Han Chinese (Beijing)C;C 10% C;T 52% T;T 39%
- Japanese (Tokyo)C;C 11% C;T 41% T;T 49%
- Yoruba (Nigeria)C;C 71% C;T 27% T;T 2%
- African ancestry (Southwest US)C;C 53% C;T 39% T;T 9%
- Chinese (Denver)C;C 12% C;T 42% T;T 46%
- Gujarati IndianC;C 24% C;T 55% T;T 22%
- Luhya (Kenya)C;C 59% C;T 36% T;T 6%
- Mexican ancestry (Los Angeles)C;C 26% C;T 55% T;T 19%
- Maasai (Kenya)C;C 58% C;T 39% T;T 4%
- TuscanC;C 18% C;T 54% T;T 28%
Related
Other CDKN2B-AS1 SNPs
- rs4977574G;GMost studies find a somewhat elevated (~1.5x) risk for myocardial infarctionMinor
- rs17756311A;APossible higher risk of childhood acute lymphoblastic leukemiaMinor
- rs1011970G;Gcommon in complete genomicsTypical
- rs10116277G;TNo summary available.Typical
- rs10757274A;AnormalTypical
- rs10965235C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs10757272 increases susceptibility to Coronary artery disease 1.30 times for heterozygotes (CT) and 1.54 times for homozygotes (TT)
Source and license
Adapted from rs10757272 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.