rs10116277
A SNP in the CDKN2B-AS1 gene on chromosome 9. Its most notable genotype is G;T.
- Gene
- CDKN2B-AS1
- Location
- Chr 922,081,398 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 35%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;T 34%
- European ancestry (Utah)G;T 49%
- Han Chinese (Beijing)G;T 49%
- Japanese (Tokyo)G;T 39%
- Yoruba (Nigeria)G;T 3%
- African ancestry (Southwest US)G;T 21%
- Chinese (Denver)G;T 40%
- Gujarati IndianG;T 55%
- Luhya (Kenya)G;T 7%
- Mexican ancestry (Los Angeles)G;T 52%
- Maasai (Kenya)G;T 6%
- TuscanG;T 56%
Related
Conditions, medicines and genes
Other CDKN2B-AS1 SNPs
- rs10757272T;T1.54x increased risk for Coronary artery diseaseWorth knowing
- rs4977574G;GMost studies find a somewhat elevated (~1.5x) risk for myocardial infarctionMinor
- rs17756311A;APossible higher risk of childhood acute lymphoblastic leukemiaMinor
- rs1011970G;Gcommon in complete genomicsTypical
- rs10757274A;AnormalTypical
- rs10965235C;Ccommon in complete genomicsTypical
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
discussed in this blog postA region of chromosome 9p21 has revealed numerous SNPs correlated with risk of myocardial infarction in a study of 2,000+ patients. This SNP, rs10116277, is highly correlated (r 2 =0.9) with rs2383207, as well as rs1333040 (r 2 =0.67). Ultimately, though, the SNP in this study (and region) with the highest disease correlation is rs10757278. According to a DeCode report, the G allele of his SNP is associated with lower risk of abdominal aortic aneurysm (AAA).
Source and license
Adapted from rs10116277 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.