rs4977574
A SNP in the CDKN2B-AS1 gene on chromosome 9. Its most notable genotype is G;G: Most studies find a somewhat elevated (~1.5x) risk for myocardial infarction
- Gene
- CDKN2B-AS1
- Location
- Chr 922,098,575 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 42%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon
- A;GBadSome studies - but not others - report a slightly increased risk for myocardial infarction
- G;GMost notableBadMost studies find a somewhat elevated (~1.5x) risk for myocardial infarction
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 40% A;G 43% G;G 16%
- European ancestry (Utah)A;A 29% A;G 50% G;G 21%
- Han Chinese (Beijing)A;A 25% A;G 53% G;G 22%
- Japanese (Tokyo)A;A 25% A;G 49% G;G 27%
- Yoruba (Nigeria)A;A 82% A;G 18% G;G <1%
- African ancestry (Southwest US)A;A 60% A;G 35% G;G 5%
- Chinese (Denver)A;A 35% A;G 39% G;G 27%
- Gujarati IndianA;A 30% A;G 51% G;G 20%
- Luhya (Kenya)A;A 60% A;G 35% G;G 6%
- Mexican ancestry (Los Angeles)A;A 26% A;G 55% G;G 19%
- Maasai (Kenya)A;A 58% A;G 38% G;G 4%
- TuscanA;A 17% A;G 56% G;G 28%
Related
Conditions, medicines and genes
Other CDKN2B-AS1 SNPs
- rs10757272T;T1.54x increased risk for Coronary artery diseaseWorth knowing
- rs17756311A;APossible higher risk of childhood acute lymphoblastic leukemiaMinor
- rs1011970G;Gcommon in complete genomicsTypical
- rs10116277G;TNo summary available.Typical
- rs10757274A;AnormalTypical
- rs10965235C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs4977574 increases susceptibility to Coronary artery disease 1.30 times for heterozygotes (A;G) and 1.54 times for homozygotes (G;G) rs4977574 was found to be associated with myocardial infarction based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs. . In this study of 2,000 patients, rs4977574(G;G) homozygotes had an increased risk (odds ratio) for myocardial infarction of 1.84 (CI: 1.14−3.09, p = 0.011)
Source and license
Adapted from rs4977574 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.