rs10801935

A SNP in the VTCN1 gene on chromosome 1. Its most notable genotype is C;C: 0.3x decreased risk of breast cancer

Gene
VTCN1
Location
Chr 1117,179,265 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.036% of people
  2. A;CNot ratednormalTypical · 0.039% of people
  3. C;CMost notableGood0.3x decreased risk of breast cancerMinor · 1.625% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 36% A;C 39% C;C 25%
  • European ancestry (Utah)A;A 42% A;C 43% C;C 16%
  • Han Chinese (Beijing)A;A 69% A;C 27% C;C 4%
  • Japanese (Tokyo)A;A 58% A;C 41% C;C 2%
  • Yoruba (Nigeria)A;A 5% A;C 42% C;C 53%
  • African ancestry (Southwest US)A;A 18% A;C 51% C;C 32%
  • Chinese (Denver)A;A 73% A;C 22% C;C 5%
  • Gujarati IndianA;A 37% A;C 45% C;C 19%
  • Luhya (Kenya)A;A 9% A;C 44% C;C 47%
  • Mexican ancestry (Los Angeles)A;A 55% A;C 33% C;C 12%
  • Maasai (Kenya)A;A 2% A;C 37% C;C 62%
  • TuscanA;A 33% A;C 46% C;C 22%

Conditions, medicines and genes

Other VTCN1 SNPs

All VTCN1 SNPs

Notes

From SNPedia

Notes

rs10801935 is a SNP in the V-set domain containing T cell activation inhibitor 1 VTCN1 gene, which is also known as B7-H4. A study of 500 Chinese Han women with breast cancer (and an equal number of matched controls) concluded that the rs10801935(C;C) genotype showed a significantly decreased risk of breast cancer (odds ratio 0.328, CI: 0.145-0.739).

Source and license

Adapted from rs10801935 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.